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Variations in ATP7B in cats with primary copper-associated hepatopathy

Posted on 2019-11-06 - 13:11
Objectives

Primary copper-associated hepatopathy (PCH) has been reported in young cats. Although our group recently reported a young cat with PCH harbouring single-nucleotide variations in ATP7B, limited information is available regarding its association with the pathogenesis of feline PCH. The objective of this study was to investigate the prevalence of ATP7B variations in cats with PCH.

Methods

Rhodanine staining was performed to detect hepatic copper accumulation (HCA) in intraoperative liver tissue specimens from 54 cats. In cats with HCA, variations in ATP7B and COMMD1 and serum ceruloplasmin activity were analysed.

Results

Based on age, liver histopathological findings and hepatic distribution of accumulated copper, PCH was suspected in 4/54 cats. Sequence analysis of ATP7B and COMMD1 revealed single-nucleotide variations in ATP7B in 3/4 cats with PCH. Among cats with PCH one showed remarkably low serum ceruloplasmin activity, while the other three did not.

Conclusions and relevance

The results of this study suggest that some cats with PCH harbour single-nucleotide variations in ATP7B, suggesting that feline PCH is an equivalent disorder to human Wilson’s disease. This study provides basic evidence facilitating further studies of the pathophysiology and treatment of feline PCH.

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Journal of Feline Medicine and Surgery

AUTHORS (10)

Hajime Asada
James K Chambers
Mari Kojima
Yuko Goto-Koshino
Taisuke Nakagawa
Nozomu Yokoyama
Masaya Tsuboi
Kazuyuki Uchida
Hajime Tsujimoto
Koichi Ohno
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