Postoperative adjuvant transarterial chemoembolization improves the prognosis of hepatocellular carcinoma patients with microvascular invasion: a systematic review and meta-analysis

Published on 2020-08-02T02:06:12Z (GMT) by
<div>Background<p>Microvascular invasion has been widely accepted as a major risk factor of hepatocellular carcinoma prognoses after surgery. It is still controversial whether postoperative adjuvant transarterial chemoembolization could improve the survival of hepatocellular carcinoma patients with microvascular invasion.</p>Purpose<p>To evaluate the effect of postoperative adjuvant transarterial chemoembolization for postoperative hepatocellular carcinoma patients with microvascular invasion.</p>Material and Methods<p>PubMed, Web of Science, and Embase databases were searched for eligible studies, and the one-, three-, and five-year recurrence rates and overall survival rates were extracted for meta-analysis.</p>Results<p>A total of eight studies were included in this study. The results showed that the one-, three-, and five-year recurrence rate of the postoperative adjuvant transarterial chemoembolization group were better than those of the hepatectomy alone group, with a pooled risk ratio (RR) of 0.66 (95% confidence interval [CI] 0.58–0.75, <i>P</i> < 0.00001), 0.82 (95% CI 0.76–0.88, <i>P</i> < 0.00001), and 0.89 (95% CI 0.82–0.97, <i>P</i> = 0.007), respectively. The overall survival rates with one-, three-, and five-year pooled RR were 0.34 (95% CI 0.25–0.47, <i>P</i> < 0.00001), 0.69 (95% CI 0.60–0.79, <i>P</i> < 0.00001), and 0.78 (95% CI 0.69–0.89, <i>P</i> = 0.0001), respectively. No serious side effects have been reported, indicating that postoperative intervention is safe.</p>Conclusion<p>For hepatocellular carcinoma patients with microvascular invasion confirmed by postoperative pathology, postoperative adjuvant transarterial chemoembolization is a safe treatment, which could reduce the tumor recurrence rate and improve the patient’s overall survival.</p></div>

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Li, Lian; Li, Bo; Zhang, Ming (2019): Postoperative adjuvant transarterial chemoembolization improves the prognosis of hepatocellular carcinoma patients with microvascular invasion: a systematic review and meta-analysis. SAGE Journals. Collection. https://doi.org/10.25384/SAGE.c.5080224.v1