SAGE Journals
Browse

New Neo-Lignan From Acanthopanax senticosus and the Cytotoxic Effects on Human Cancer Cell Lines

Posted on 2020-07-22 - 12:11

A new neo-lignan named (7ʹS,8ʹR)-4ʹ,5ʹ,9ʹ-trihydroxy-5-methoxy-4,8ʹ-oxyneolign-7-en-9-al (1), together with 5 known compounds (2-6) were isolated from the ethylacetate-soluble extract of Acanthopanax senticosus. The structure of new neo-lignan was elucidated with spectroscopic and physicochemical analyses. All the isolates were evaluated for in vitro cytotoxicity against 4 human cancer lines including HepG2, A549, Hela, and MCF-7. Among them, compounds 1 and 3 showed the potent antiproliferative activities against the HepG2 cancer cells with half-maximal inhibitory concentration (IC50) values of 9.8 ± 1.6 and 15.0 ± 1.1 μM, respectively. In addition, compound 6 exhibited moderate inhibitory activity on MCF-7 cancer cells with an IC50 value of 18.3 ± 1.5 μM.

CITE THIS COLLECTION

DataCite
3 Biotech
3D Printing in Medicine
3D Research
3D-Printed Materials and Systems
4OR
AAPG Bulletin
AAPS Open
AAPS PharmSciTech
Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg
ABI Technik (German)
Academic Medicine
Academic Pediatrics
Academic Psychiatry
Academic Questions
Academy of Management Discoveries
Academy of Management Journal
Academy of Management Learning and Education
Academy of Management Perspectives
Academy of Management Proceedings
Academy of Management Review
or
Select your citation style and then place your mouse over the citation text to select it.

SHARE

email
need help?