Natural Cembrane Diterpenoids From the Soft Coral Sinularia querciformis
Posted on 2021-12-02 - 13:28
Chemical examination of Sinularia querciformis afforded one new cembranoid, querciformolide F (1), along with four known cembranoids, sinulariolone (2), granosolide A (3), querciformolide A (4), and sinulariolide (5). The structures of these compounds were determined by extensive spectroscopic (IR, ESIMS, 1H NMR, and 13C NMR) analysis and by comparison with those previously reported in the literature. Compounds 2 to 4 were found to exhibit significant anti-inflammatory activity in lipopolysaccharide (LPS)-induced RAW264.7 mouse macrophages through attenuating the expression of the inducible nitric oxide synthase (iNOS) proteins.
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Wu, Yi-Ying; Hsieh, Chia-Ching; Li, Chia-Ying; Chang, Wen-Huei; Chen, Jih-Jung; Lai, Kuei-Hung; et al. (2021). Natural Cembrane Diterpenoids From the Soft Coral Sinularia querciformis. SAGE Journals. Collection. https://doi.org/10.25384/SAGE.c.5733780.v1
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AUTHORS (8)
YW
Yi-Ying Wu
CH
Chia-Ching Hsieh
CL
Chia-Ying Li
WC
Wen-Huei Chang
JC
Jih-Jung Chen
KL
Kuei-Hung Lai
ZW
Zhi-Hong Wen
HC
Hsu-Ming Chung