Natural Cembrane Diterpenoids From the Soft Coral Sinularia querciformis

Posted on 2021-12-02 - 13:28

Chemical examination of Sinularia querciformis afforded one new cembranoid, querciformolide F (1), along with four known cembranoids, sinulariolone (2), granosolide A (3), querciformolide A (4), and sinulariolide (5). The structures of these compounds were determined by extensive spectroscopic (IR, ESIMS, 1H NMR, and 13C NMR) analysis and by comparison with those previously reported in the literature. Compounds 2 to 4 were found to exhibit significant anti-inflammatory activity in lipopolysaccharide (LPS)-induced RAW264.7 mouse macrophages through attenuating the expression of the inducible nitric oxide synthase (iNOS) proteins.

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Wu, Yi-Ying; Hsieh, Chia-Ching; Li, Chia-Ying; Chang, Wen-Huei; Chen, Jih-Jung; Lai, Kuei-Hung; et al. (2021): Natural Cembrane Diterpenoids From the Soft Coral Sinularia querciformis. SAGE Journals. Collection. https://doi.org/10.25384/SAGE.c.5733780.v1
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AUTHORS (8)

Yi-Ying Wu
Chia-Ching Hsieh
Chia-Ying Li
Wen-Huei Chang
Jih-Jung Chen
Kuei-Hung Lai
Zhi-Hong Wen
Hsu-Ming Chung
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