MicroRNA-215-3p Suppresses the Growth, Migration, and Invasion of Colorectal Cancer by Targeting FOXM1

Published on 2019-10-14T12:06:12Z (GMT) by
<div><p>Previous investigations have indicated that microRNA-215-3p is dysregulated in many kinds of cancers and functions as oncogene or tumor suppressor. However, the potential role of microRNA-215-3p in the progression of colorectal cancer remains not well known. Herein, we demonstrated that microRNA-215-3p was downregulated in human colorectal cancer tissues and was reversely correlated to the lymph node metastasis of colorectal cancer. Overexpression of microRNA-215-3p inhibited the clonogenic abilities and metastasis-relevant traits of colorectal cancer cell <i>in vitro</i>. Consistently, upregulation of microRNA-215-3p inhibited the growth and metastasis of colorectal cancer cell <i>in vivo</i>. Forkhead box protein M1 was identified as a direct target of microRNA-215-3p and reexpression of forkhead box protein M1 reversed the suppressive impacts of microRNA-215-3p on the growth, mobility, and invasion abilities of colorectal cancer cell. Altogether, these results revealed the vital role of microRNA-215-3p in the tumorigenesis and metastasis of colorectal cancer.</p></div>

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Tang, Xiaowei; Shi, Xianfeng; Wang, Nianfei; Peng, Wanren; Cheng, Zhendong (2019): MicroRNA-215-3p Suppresses the Growth, Migration, and Invasion of Colorectal Cancer by Targeting FOXM1. SAGE Journals. Collection. https://doi.org/10.25384/SAGE.c.4697108.v1