Head Motion During MRI Predicted by out-of-Scanner Sustained Attention Performance in Attention-Deficit/Hyperactivity Disorder

Published on 2020-03-20T12:07:56Z (GMT) by
<div><p><b>Objective:</b> To characterize head movements in children with ADHD using an ex-Gaussian distribution and examine associations with out-of-scanner sustained attention. <b>Method:</b> Fifty-six children with ADHD and 61 controls aged 9 to 11 years completed the Sustained Attention to Response Task (SART) and resting-state functional magnetic resonance imaging (fMRI). In-scanner head motion was calculated using ex-Gaussian estimates for mu, sigma, and tau in delta variation signal and framewise displacement. Sustained attention was evaluated through omission errors and tau in response time on the SART. <b>Results:</b> Mediation analysis revealed that out-of-scanner attention lapses (omissions during the SART) mediated the relationship between ADHD diagnosis and in-scanner head motion (tau in delta variation signal), indirect effect: <i>B</i> = 1.29, 95% confidence interval (CI) = [0.07, 3.15], accounting for 29% of the association. <b>Conclusion:</b> Findings suggest a critical link between trait-level sustained attention and infrequent large head movements during scanning (tau in head motion) and highlight fundamental challenges in measuring the neural basis of sustained attention.</p></div>

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Thomson, Phoebe; Johnson, Katherine A.; Malpas, Charles B.; Efron, Daryl; Sciberras, Emma; Silk, Timothy J. (2020): Head Motion During MRI Predicted by out-of-Scanner Sustained Attention Performance in Attention-Deficit/Hyperactivity Disorder. SAGE Journals. Collection. https://doi.org/10.25384/SAGE.c.4902168.v1