Differential vulnerability of thalamic nuclei in multiple sclerosis

Posted on 2022-08-13 - 12:09
Objectives:

Investigating differential vulnerability of thalamic nuclei in multiple sclerosis (MS).

Methods:

In a secondary analysis of prospectively collected datasets, we pooled 136 patients with MS or clinically isolated syndrome and 71 healthy controls all scanned with conventional 3D-T1 and white-matter-nulled magnetization-prepared rapid gradient echo (WMn-MPRAGE) and tested for cognitive performance. T1-based thalamic segmentation was compared with the reference WMn-MPRAGE method. Volumes of thalamic nuclei were compared according to clinical phenotypes and cognitive profile.

Results:

T1- and WMn-MPRAGE provided comparable segmentations (0.84 ± 0.13 < volume-similarity-index < 0.95 ± 0.03). Medial and posterior thalamic groups were significantly more affected than anterior and lateral groups. Cognitive impairment related to volume loss of the anterior group.

Conclusion:

Thalamic nuclei closest to the third ventricle are more affected, with cognitive consequences.

CITE THIS COLLECTION

Blyau, Simon; Koubiyr, Ismail; Saranathan, Manojkumar; Coupé, Pierrick; Deloire, Mathilde; Charré-Morin, Julie; et al. (2022): Differential vulnerability of thalamic nuclei in multiple sclerosis. SAGE Journals. Collection. https://doi.org/10.25384/SAGE.c.6146904.v1
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Multiple Sclerosis Journal

AUTHORS (13)

Simon Blyau
Ismail Koubiyr
Manojkumar Saranathan
Pierrick Coupé
Mathilde Deloire
Julie Charré-Morin
Aurore Saubusse
Bei Zhang
Brian Rutt
Vincent Dousset
Bruno Brochet
Aurélie Ruet
Thomas Tourdias
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