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Cognition, ADHD Symptoms, and Functional Impairment in Children and Adolescents With Neurofibromatosis Type 1

Posted on 2019-12-15 - 13:06

Objective: We examined the contribution of attention and executive cognitive processes to ADHD symptomatology in NF1, as well as the relationships between cognition and ADHD symptoms with functional outcomes. Methods: The study sample consisted of 141 children and adolescents with NF1. Children were administered neuropsychological tests that assessed attention and executive function, from which latent cognitive variables were derived. ADHD symptomatology, adaptive skills, and quality of life (QoL) were assessed using parent-rated questionnaires. Path analyses were conducted to test relationships among cognitive functioning, ADHD symptomatology, and functional outcomes. Results: Significant deficits were observed on all outcome variables. Cognitive variables did not predict ADHD symptomatology. Neither did they predict functional outcomes. However, elevated ADHD symptomatology significantly predicted functional outcomes. Conclusion: Irrespective of cognitive deficits, elevated ADHD symptoms in children with NF1 negatively impact daily functioning and emphasize the importance of interventions aimed at minimizing ADHD symptoms in NF1.

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Journal of Attention Disorders

AUTHORS (21)

Jonathan M. Payne
Kristina M. Haebich
Rachel MacKenzie
Karin S. Walsh
Stephen J. C. Hearps
David Coghill
Belinda Barton
Natalie A. Pride
Nicole J. Ullrich
James H. Tonsgard
David Viskochil
Elizabeth K. Schorry
Laura Klesse
Michael J. Fisher
David H. Gutmann
Tena Rosser
Roger J. Packer
Bruce Korf
Maria T. Acosta
Mark A. Bellgrove
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