Cerebrovascular disease is associated with an increased disease severity in patients with Coronavirus Disease 2019 (COVID-19): A pooled analysis of published literature

Published on 2020-04-21T12:09:08Z (GMT) by
<div>Introduction<p>There is an urgent need to identify patients at high risk during the ongoing coronavirus disease (COVID-19) pandemic. Whether a history of stroke is associated with increased severity of disease or mortality is unknown.</p>Method<p>We pooled studies from published literature to assess the association of a history of stroke with outcomes in patients with COVID-19.</p>Results<p>A pooled analysis of 4 studies showed a ∼2.5-fold increase in odds of severe COVID-19. While a trend was observed, there was no statistically significant association of stroke with mortality in patients with COVID-19 infection.</p>Discussion<p>Our findings are limited by a small number of studies and sample size.</p>Conclusion<p>There is a ∼2.5-fold increase in odds of severe COVID-19 illness with a history of cerebrovascular disease.</p></div>

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Aggarwal, Gaurav; Lippi, Giuseppe; Michael Henry, Brandon (2020): Cerebrovascular disease is associated with an increased disease severity in patients with Coronavirus Disease 2019 (COVID-19): A pooled analysis of published literature. SAGE Journals. Collection. https://doi.org/10.25384/SAGE.c.4946271.v1