Association of interleukin 10 rs1800896 polymorphism with susceptibility to breast cancer: a meta-analysis
To evaluate the correlation between interleukin 10 (IL-10) −1082A/G polymorphism (rs1800896) and breast cancers by performing a meta-analysis.
MethodsThe Embase and Medline databases were searched through 1 September 2018 to identify qualified articles. Odds ratios (OR) and corresponding 95% confidence intervals (CIs) were applied to evaluate associations.
ResultsIn total, 14 case-control studies, including 5320 cases and 5727 controls, were analyzed. We detected significant associations between the IL10 −1082 G/G genotype and risk of breast cancer (AA + AG vs. GG: OR = 0.88, 95% CI = 0.80–0.97). Subgroup analyses confirmed a significant association in Caucasian populations (OR = 0.89, 95% CI = 0.80–0.99), in population-based case-control studies (OR = 0.87, 95% CI = 0.78–0.96), and in studies with ≥500 subjects (OR = 0.88, 95% CI = 0.79–0.99) under the recessive model (AA + AG vs. GG). No associations were found in Asian populations.
ConclusionsThe IL10 −1082A/G polymorphism is associated with an increased risk of breast cancer. The association between IL10 −1082 G/G genotype and increased risk of breast cancer is more significant in Caucasians, in population-based studies, and in larger studies.
CITE THIS COLLECTION
SHARE
Usage metrics
Read the peer-reviewed publication
AUTHORS (4)
CATEGORIES
- Health and Community Services
- Cardiology
- Dentistry not elsewhere classified
- Emergency Medicine
- Endocrinology
- Geriatrics and Gerontology
- Neurology and Neuromuscular Diseases
- Nursing not elsewhere classified
- Nutrition and Dietetics not elsewhere classified
- Oncology and Carcinogenesis not elsewhere classified
- Orthopaedics
- Sports Medicine
- Otorhinolaryngology
- Aged Health Care
- Paediatrics
- Pharmacology and Pharmaceutical Sciences not elsewhere classified
- Psychology not elsewhere classified
- Psychiatry (incl. Psychotherapy)
- Public Health and Health Services not elsewhere classified
- Respiratory Diseases
- Sociological Methodology and Research Methods
- Surgery