An improved method for the synthesis of phenylacetic acid derivatives via carbonylation

Published on 2019-10-09T12:07:57Z (GMT) by
<div><p>2,4-Dichlorophenylacetic acid is synthesized in high yield via the carbonylation of 2,4-dichlorobenzyl chloride, and various experimental conditions are evaluated. Xylene, bistriphenylphosphine palladium dichloride, tetraethylammonium chloride and sodium hydroxide in solution are added to the reaction system and held at 80 °C under a CO atmosphere. 2,4-Dichlorophenylacetic acid is obtained in a maximum yield of 95%, and a mechanism for 2,4-dichlorobenzyl chloride carbonylation is proposed. The reaction system provides a mild, effective and novel means by which to prepare phenylacetic acid derivatives from their corresponding benzyl chloride derivatives.</p></div>

Cite this collection

Li, He; Zhang, Yijun; Liu, Dinghua; Liu, Xiaoqin (2019): An improved method for the synthesis of phenylacetic acid derivatives via carbonylation. SAGE Journals. Collection.