An improved method for the synthesis of phenylacetic acid derivatives via carbonylation
Posted on 2019-10-09 - 12:07
2,4-Dichlorophenylacetic acid is synthesized in high yield via the carbonylation of 2,4-dichlorobenzyl chloride, and various experimental conditions are evaluated. Xylene, bistriphenylphosphine palladium dichloride, tetraethylammonium chloride and sodium hydroxide in solution are added to the reaction system and held at 80 °C under a CO atmosphere. 2,4-Dichlorophenylacetic acid is obtained in a maximum yield of 95%, and a mechanism for 2,4-dichlorobenzyl chloride carbonylation is proposed. The reaction system provides a mild, effective and novel means by which to prepare phenylacetic acid derivatives from their corresponding benzyl chloride derivatives.
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Li, He; Zhang, Yijun; Liu, Dinghua; Liu, Xiaoqin (2019). An improved method for the synthesis of phenylacetic acid derivatives via carbonylation. SAGE Journals. Collection. https://doi.org/10.25384/SAGE.c.4691978.v1
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AUTHORS (4)
HL
He Li
YZ
Yijun Zhang
DL
Dinghua Liu
XL
Xiaoqin Liu